Composition – F-BOD http://f-bod.com/ Fri, 30 Sep 2022 14:46:06 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://f-bod.com/wp-content/uploads/2021/09/fbod-150x150.png Composition – F-BOD http://f-bod.com/ 32 32 Riot Mortdog Responds To TFT Set 7 Balance Complaints: “You Can’t Please Everyone” https://f-bod.com/riot-mortdog-responds-to-tft-set-7-balance-complaints-you-cant-please-everyone/ Fri, 30 Sep 2022 13:48:05 +0000 https://f-bod.com/riot-mortdog-responds-to-tft-set-7-balance-complaints-you-cant-please-everyone/ Meg Kay ❘ Published: 2022-09-30T13:29:34 ❘ Updated: 2022-09-30T13:29:54 In response to a recent Reddit post criticizing TFT’s balancing system, Mortdog explained that the game has yet to strike the “perfect balance” between optimization for hardcore and casual gamers. Since its release, Teamfight Tactics has attracted a wide range of players, from hardcore rated climbers to […]]]>

Published: 2022-09-30T13:29:34

Updated: 2022-09-30T13:29:54

In response to a recent Reddit post criticizing TFT’s balancing system, Mortdog explained that the game has yet to strike the “perfect balance” between optimization for hardcore and casual gamers.

Since its release, Teamfight Tactics has attracted a wide range of players, from hardcore rated climbers to more casual audiences. This universal appeal is part of what makes TFT such a difficult game to balance – something lead game developer Steven ‘Mortdog’ Mortimer recently addressed in response to a post on the Competitive TFT subreddit by Reddit user u /idontlikeredditbutok, criticizing the status of the game’s most recent update, Set 7.5.

Mortdog has often been praised by the community for his constant communication with the playerbase – letting players know the processes behind decisions made with Twitter feeds and posts on the TFT subreddit.

The original post broke the idea of ​​comp variance, which is essentially the ability to squeeze other units into a team comp while still keeping that comp functional. The poster pointed out that their main problem with the current set was how little variance there seemed to be in the popular lineups.

The post went on to explain that the larger balance issue in recent TFT sets is that comps “aged” much faster than they did in previous sets, and the game had become inherently less fun to play.

Mortdog’s response

Mortdog was quick to respond to the original post. In his response, he described some of the difficulties with balance that had led to the original poster’s frustrations. Namely, that complaints about TFT’s balance tend to be biased towards the experience of high elo players, and that those players tend to forget that a high percentage of the player base only plays for the pleasure.

While higher elo players tend to prefer champions who can fit into multiple comps and run comps with a wide range of traits, lower elo players prefer to index hard into unique traits. This leads to what Mortdog describes as a “fundamental contradiction” in TFT balancing.

“In instances where the vertical strokes aren’t strong, a large portion of our player base feels their expectations are betrayed and may stop playing the game,” Mortdog explained, responding to complaints from the original poster. regarding the lack of flexibility regarding the substitution of traits in compositions.

He went on to add that the balance of TFT is by no means “solved” and that it is very difficult to balance a game whose approach to the playerbase plays in such a fundamentally different way. He explained that no set managed to strike the “perfect balance of key verticals” that the developers were looking for.

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How low-code compounding transformed lender Pepper Money https://f-bod.com/how-low-code-compounding-transformed-lender-pepper-money/ Wed, 28 Sep 2022 16:28:47 +0000 https://f-bod.com/how-low-code-compounding-transformed-lender-pepper-money/ You can get a measure of a man from how he describes his job. When Steven Meek, CIO of Pepper Money, speaks to us from the company’s state-of-the-art headquarters in Sydney, Australia, the workday has gone well. Many of his colleagues return home and a well-meaning cleaner vacuums the sparse office. Still, Meek is brimming […]]]>

You can get a measure of a man from how he describes his job. When Steven Meek, CIO of Pepper Money, speaks to us from the company’s state-of-the-art headquarters in Sydney, Australia, the workday has gone well. Many of his colleagues return home and a well-meaning cleaner vacuums the sparse office. Still, Meek is brimming with enthusiasm for the role he plays, describing his work as if it were an honor, not a calling.

“It’s great,” he said. “I feel privileged to lead a very talented team, working on digital transformation, data and analytics, and core technology services and solutions. I have been fortunate throughout my career to have worked in multiple industries, from IT services and consumer goods to investment banking, helping every company I worked for through times of major change.

This description is no less applicable to Pepper Money, which Meek joined in 2021. Founded in 2000, the lender began with mortgages, focusing on customers who could not access financing through traditional means – whether it was because they had a flawed credit history, unpredictable income habits or a life event that changed their financial situation. For more than two decades, Pepper Money has steadily strengthened its lending solutions with new offerings covering homes, cars, electric vehicles (EVs), equipment, asset finance, commercial real estate and loans. personal.

“As a company, we have industry-leading turnaround times, innovative technology established over many years, and a team of over 1,000 people who have helped 327,000 customers from all walks of life,” Says Meek. “We are now one of the largest and most trusted non-bank lenders in Australia and New Zealand.”

Out-of-the-box solutions in place were not working

Pepper Money’s rise is based on the fact that, to some extent, it has avoided some of the legacy issues that plague incumbent lenders – in part because, as a relatively young and nimble organization, it has managed to limit its exposure to legacy technology. Today, 90% of its digital architecture runs through cloud and SaaS platforms, ensuring a balance between resilience, agility and profitability. Every lender tries to make that application experience faster and more seamless, Meek says, but success still relies heavily on manual processes for many.

“Our digitization journey started in 2018 when it was clear that we were facing an increasingly digital and competitive market,” says Meek. “We recognized early on that our out-of-the-box ready solutions in place needed to be redesigned. The strategic review of our digital architecture and the unpacking of all our front-office and back-office processes have been a major priority. As part of this, we made the decision in 2019 to look to composable and low-code digital solutions to rapidly transform our origination channels and increase the level of innovation in the employee and customer experience.

Among the new capabilities being invested, Pepper Money has partnered with Appian, the US-based software company, to completely redesign its digital architecture. The digital asset finance origination platform it built, Solana, has driven a 70% increase in business volumes and brings Pepper’s proprietary credit decision capabilities to the forefront, using AI-powered analytics for automated approval.

“Our existing solutions were hosted on-premises, lacked flexibility, and as a result were not responsive enough to the changing needs of a rapidly growing and diversifying lending business,” Meek recalls.

“We needed something that could scale at pace and had all the benefits of cloud-only elastic scalability and security. We wanted something that could activate a market for acceleration solutions, that would allow us to harness innovation much faster than we could do internally. All of these factors and the global scale Appian was able to bring contributed to the partnership we enjoy with them today. »

Pepper Money takes advantage of low-code composition

For Pepper Money, the advantages of low-code platforms are fourfold. The first benefit is obvious: low-code builders allow businesses to significantly reduce their speed to market, which in Pepper Money’s case is the time a consumer waits for approval. No one applies for credit to experience delays and denials, so making quick and informed credit decisions is essential.

Appian also offers the lender seamless integration with existing infrastructure, because by obtaining this right, Pepper Money is able to coordinate complex workflows involving many systems without exposing those systems directly to the end customer or employee.

“Once again, the key is ease of use,” adds Meek. “Appian’s building blocks and accelerator components mean we can accelerate time to market without having to build from scratch.

“The final benefit is what we call talent resiliency, and to be honest, we haven’t tapped into the full potential of that yet. We recognize that the longer-term benefit of low-code is to enable the citizen development, where business teams with basic computer and coding knowledge can build apps, workflows, and processes in minutes.

Innovation is at the heart of Pepper Money’s culture

In today’s world, where consumers and businesses must deal with soaring food and fuel prices, lenders play a more central role than ever. Innovation is key if lenders like Pepper Money are to keep pace with the needs of their customers.

Meek explains: “Like many economies around the world, the combined effect of rising inflation and rising interest rates means that our clients, brokers and introducers are facing a period of uncertainty. It’s a critical time right now for people to have peace of mind, quick decisions, and flexible loan options. From a digital and technology perspective, this means speed of decision-making, access to self-service options, transparency throughout the digital journey, and more automation for our internal employees – all of which are crucial right now. to help our customers meet these challenges.

As an example, he cites Pepper Money’s average loan approval rates reported last year: an impressive 85% of all mortgage applications are approved within a day, and 42% of Asset financing are automatically approved – made possible by Pepper fully embracing automation technologies. Rather than resting on its laurels, the lender continues to explore new uses for technology and realize new cost savings.

“Our continued investment in technology innovations – like smart document scanning, digital signatures, biometrics, automated assessments, digital income verification and things like AI-based analytics for our credit assessors – will continue to enable us to evolve our products and serve customers in the future.”

From a front-end perspective, this also means benefits for Pepper Money customers. With its digital self-service platform, they can easily view their payment amount, download statements, and control payments all in one place. There is also a set of personalized communications that keep them informed throughout their credit journey.

Towards a clear vision of the future

As Pepper Money continues to grow and prosper, it will look for new potential to add value. For example, in electric vehicle financing, Pepper Money recently partnered with Evie Networks to offer customers who finance their electric vehicle with Pepper Money a public charging subscription plan for 12 months at no cost.

“People come to Pepper for a purpose,” Meek says. “It’s more about the overall value we can offer them and the service we provide, more than just price and credit.”

“We will continue to invest in technology as the backbone of our business process management, creation, maintenance, customer service and enterprise capabilities. We want our clients, brokers and introducers to have a fast and frictionless experience, and we want our employees to have the same. They need to have confidence in the data they work with and they need to feel able to successfully navigate our increasingly digitized processes. The low-code, cloud-first platforms we use are fundamental to continuing to ensure that we can scale effectively as a business into the future. »

“Over the next 12-18 months, we will be focused on leveraging all available continuous innovation opportunities, ranging from leveraging Open Finance to enable new services and smoother customer experiences, to rapidly expanding our use of automated identity verification and in pursuit of real-time analytics integration that allows our employees to have the necessary information at their fingertips that drives pricing, products and customer decisions faster than ever before.

Clearly, the proof will be in the customer experience. Beyond transparent pricing and a range of products that resonate with them, the main thing applicants want from lenders during the application process is a quick decision and a clear rationale for any decision. Pepper Money has already served 327,000 customers; now he hopes his roadmap for the future will allow him to empower even more clients to succeed.

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Solvent Study Solves Solar Cell Durability Puzzle, Energy News, ET EnergyWorld https://f-bod.com/solvent-study-solves-solar-cell-durability-puzzle-energy-news-et-energyworld/ Sat, 24 Sep 2022 01:20:00 +0000 https://f-bod.com/solvent-study-solves-solar-cell-durability-puzzle-energy-news-et-energyworld/ Washington: The fabrication of high-efficiency solar cells with 2D and 3D perovskite layers can be simplified by solvents that allow solution deposition of one layer without destroying the other. It required finding the right solvent design to apply a 2D top layer of desired composition and thickness without destroying the 3D bottom layer (or vice […]]]>

Washington: The fabrication of high-efficiency solar cells with 2D and 3D perovskite layers can be simplified by solvents that allow solution deposition of one layer without destroying the other.

It required finding the right solvent design to apply a 2D top layer of desired composition and thickness without destroying the 3D bottom layer (or vice versa). Such a cell would convert more sunlight into electricity than either layer alone, with better stability.

Chemical and biomolecular engineer Aditya Mohite and his lab at Rice’s George R. Brown School of Engineering reported in Science their success in building thin 3D/2D solar cells that offer a power conversion efficiency of 24.5 %.

It’s as efficient as most commercially available solar cells, Mohite said.

“It’s really good for flexible bifacial cells where light enters from both sides and also for cells in back contact,” he said. “2D perovskites absorb blue and visible photons, and the 3D side absorbs near infrared.”

Perovskites are crystals with cubic lattices known to be efficient light collectors, but the materials tend to be stressed by light, humidity, and heat. Mohite and many others have worked for years to make perovskite solar cells practical.

The new breakthrough, he said, largely removes the last major obstacle to commercial production.

“It’s important on many levels,” Mohite said. “The first is that it’s inherently difficult to make a solution-treated bilayer when both layers are made of the same material. The problem is that they both dissolve in the same solvents.

“When you put a 2D layer on top of a 3D layer, the solvent destroys the underlying layer,” he said. “But our new method solves this problem.”

Mohite said 2D perovskite cells are stable, but less efficient at converting sunlight. 3D perovskites are more efficient but less stable. Their combination incorporates the best features of both.

“It leads to very high yields because now, for the first time in the field, we are able to create layers with enormous control,” he said. “This allows us to control the flow of charge and energy not only for solar cells, but also for optoelectronic devices and LEDs.”

The efficiency of test cells exposed to the laboratory equivalent of 100% sunlight for more than 2,000 hours “does not degrade even 1%,” he said. Not including a glass substrate, the cells were about 1 micron thick.

Solution processing is widely used in industry and incorporates a range of techniques – spin coating, dip coating, blade coating, slot die coating and others – to deposit a material onto a surface in a liquid. When the liquid evaporates, the pure coating remains.

The key is a balance between two properties of the solvent itself: its dielectric constant and the Gutmann donor number. The dielectric constant is the ratio of the electrical permeability of the material to its free space. This determines how well a solvent can dissolve an ionic compound. The donor number is a measure of the electron donor ability of solvent molecules.

“If you find the correlation between them, you will find that there are about four solvents that allow you to dissolve perovskites and spin coat them without destroying the 3D layer,” Mohite said.

He said their discovery should be compatible with roll-to-roll manufacturing which typically produces 30 meters of solar cell per minute.

“This breakthrough leads, for the first time, to heterostructures of perovskite devices containing more than one active layer,” said co-author Jacky Even, professor of physics at the Institut national des sciences et technologies de Rennes, in France. “The dream of designing complex semiconductor architectures with perovskites is about to come true. New applications and the exploration of new physical phenomena will be the next steps.”

“This has implications not only for solar power, but also for green hydrogen, with cells capable of generating power and converting it to hydrogen,” Mohite said. “It could also enable off-grid solar power for cars, drones, building-integrated photovoltaics or even agriculture.”

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Researchers use muon beams to analyze elemental composition of samples from asteroid Ryugu https://f-bod.com/researchers-use-muon-beams-to-analyze-elemental-composition-of-samples-from-asteroid-ryugu/ Thu, 22 Sep 2022 18:00:10 +0000 https://f-bod.com/researchers-use-muon-beams-to-analyze-elemental-composition-of-samples-from-asteroid-ryugu/ (left) A muon X-ray created after a muon is captured by irradiated material, and (right) a sample from the asteroid Ryugu. Credit: (left image) Muon Analysis Team, (right image) JAXA Stone samples brought back to Earth from the asteroid Ryugu have had their elemental composition analyzed using a beam of muons artificially generated by the […]]]>

(left) A muon X-ray created after a muon is captured by irradiated material, and (right) a sample from the asteroid Ryugu. Credit: (left image) Muon Analysis Team, (right image) JAXA

Stone samples brought back to Earth from the asteroid Ryugu have had their elemental composition analyzed using a beam of muons artificially generated by the J-PARC particle accelerator. The researchers discovered a number of important elements needed to sustain life, including carbon, nitrogen and oxygen, but also found that the abundance of oxygen relative to silicon in asteroid Ryugu was different from all meteorites found on Earth, reports a new study in Science.

In 2014, the unmanned asteroid explorer Hayabusa 2 was launched into space by the Japan Aerospace Exploration Agency (JAXA) with the mission of bringing back samples of asteroid Ryugu, a C-type asteroid that researchers believed to be carbon-rich. After successfully landing on Ryugu and collecting samples, Hayabusa 2 returned to Earth in December 2020 with samples intact.

Since 2021, researchers have carried out the first analyzes of the samples, led by Professor Shogo Tachibana from the University of Tokyo. Divided into several teams, the researchers studied the samples in different ways, including stone shapes, elemental distribution and mineral composition.

In this study, led by Tohoku University Professor Tomoki Nakamura, Professor Tadayuki Takahashi and graduate student Shunsaku Nagasawa of the Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU), University of Tokyo, in collaboration with the High Energy Accelerator Research Organization (KEK) Institute for Materials Structure Science, Osaka University, Japan Atomic Energy Agency (JAEA), Kyoto University, International Christian University, Institute of Space and Astronautical Science (ISAS) and Tohoku University, applied elementary analysis methods using negative muons, elementary particles produced by the J-PARC accelerator.

They applied the elemental analysis method using negative muons to the stones of the asteroid Ryugu, successfully determining their elemental compositions non-destructively.

Researchers have used muon beams to analyze the elemental composition of samples from asteroid Ryugu

The bespoke experimental setup was developed to prevent the samples from being contaminated by the Earth’s atmosphere. The interior is filled with helium and the chamber is lined with pure copper to minimize background noise. Credit: Muon Analysis Team

This was important, because if the asteroids in the solar system were built early in the formation of the solar system itself, they would still retain information about the average elemental composition at that time, and therefore about the entire system solar.

Analyzes of meteorites that have fallen to Earth have been carried out in the past, but it is possible that these samples have been contaminated by the Earth’s atmosphere. Thus, until Hayabusa 2, no one knew for sure what the chemical composition of an asteroid was.

But the researchers faced a challenge. Due to the limited amount of samples and the large number of other researchers wishing to study them, they had to find a way to perform their analyzes without damaging them so that the samples could be passed on to other groups.

The team had developed a new method, which involved firing a quantum beam, or more specifically a negative muon beam, produced by one of the world’s largest high-energy particle accelerators J-PARC in the prefecture of Ibaraki, Japan, to identify chemical elements in sensitive samples without breaking them.

Researchers have used muon beams to analyze the elemental composition of samples from asteroid Ryugu

Spectral comparison of muon X-rays from the asteroid sample Ryugu and the chondrite CI Orgueil. Credit: Muon Analysis Team

Takahashi and Nagasawa then applied statistical analysis techniques in X-ray astronomy and particle physics experiments to analyze characteristic muon X-rays.

Muons are one of the elementary particles of the universe. Their ability to penetrate deeper into materials than X-rays make them ideal for materials analysis. When a negative muon is captured by the irradiated sample, a muonic atom is formed. The muonic X-rays emitted by new muonic atoms have high energy and can therefore be detected with high sensitivity. This method was used to analyze the samples from Ryugu.

But there was another challenge. In order to prevent the samples from being contaminated by the Earth’s atmosphere, the researchers had to keep the samples out of contact with oxygen and water in the air. Therefore, they had to develop an experimental setup, enclosing the sample in a helium gas chamber. The interior walls of the chamber were lined with pure copper to minimize background noise during sample analysis.

In June 2021, 0.1 grams of asteroid Ryugu was introduced into J-PARC, and the researchers performed their X-ray analysis of the muons, which produced an energy spectrum. They found there the elements necessary for the production of life, carbon, nitrogen and oxygen, but they also discovered that the sample had a composition similar to that of carbonaceous chondrite (CI chondrite) asteroids. , often called the standard for solid substances. in the solar system. This showed that the Ryugu Stones were among the first stones to form in our solar system.

Researchers have used muon beams to analyze the elemental composition of samples from asteroid Ryugu

Comparison of the elemental composition of the asteroid sample Ryugu and the chondrite CI Orgueil (K. Lodders, The Astrophysical Journal, 591, 1220-1247, 2003). Oxygen radiography shows that the oxygen abundance of Ryugu sample relative to silicon was lower than that of CI chondrite. Credit: Muon Analysis Team

However, although similar in composition to the CI chondrites, the oxygen abundance of the Ryugu sample relative to silicon was about 25% lower than that of the CI chondrite. The researchers say this could indicate that the excess oxygen relative to silicon in the CI chondrites could come from contamination after they entered the Earth’s atmosphere. The Ryugu stones could set a new standard for matter in the solar system.


Dust grains from the asteroid Ryugu older than our solar system


More information:
T. Nakamura, Formation and Evolution of the Carbonaceous Asteroid Ryugu: Direct Evidence from Returned Samples, Science (2022). DOI: 10.1126/science.abn8671. www.science.org/doi/10.1126/science.abn8671

Provided by Kavli Institute for the Physics and Mathematics of the Universe

Quote: Researchers use muon beams to analyze elemental composition of samples from asteroid Ryugu (2022, September 22) retrieved September 22, 2022 from https://phys.org/news/2022-09-muons-elemental -composition-asteroid-ryugu. html

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For metabolic health measures, body composition beats weight https://f-bod.com/for-metabolic-health-measures-body-composition-beats-weight/ Tue, 20 Sep 2022 09:34:59 +0000 https://f-bod.com/for-metabolic-health-measures-body-composition-beats-weight/ If you’ve ever thought about your weight in relation to your overall health (who hasn’t?), you’ve probably wondered how metabolism plays a role in the equation, or even what is metabolism. Metabolism is the complex biochemical process that produces the energy your cells need to function and keep your body healthy. “Metabolism isn’t just about […]]]>

If you’ve ever thought about your weight in relation to your overall health (who hasn’t?), you’ve probably wondered how metabolism plays a role in the equation, or even what is metabolism.

Metabolism is the complex biochemical process that produces the energy your cells need to function and keep your body healthy. “Metabolism isn’t just about weight. In fact, it has more to do with how our body uses the food we eat and converts it into fuel for energy,” Scheller shares.

In medical terminology, metabolism is measured by basal metabolic rate (BMR). Essentially, your BMR is the amount of energy your body needs to perform essential functions (eg breathing, blood circulation, hormone regulation) even when at rest. In other words, the higher your BMR, the faster your metabolism.

The aspect that most influences BMR is your lean body mass (i.e. lean muscle mass), which is the weight of everything but body fat (i.e. body water, organs, skin, bones). The higher your lean body mass, the more energy your body needs at rest (and the higher your BMR).

Since fat is not as metabolically active as lean muscle mass, the alternative is also true: if a body composition has a higher fat percentage, it requires less energy. As a result, people with lower lean muscle mass have lower BMR and slower metabolism.

As you can see, improving your metabolic rate and increasing your metabolism is the key to losing fat and gaining muscle (and it’s definitely not as simple as “calories in, calories out” ).

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Mitchel Johnson has delivered his verdict on India’s bowling roster for the T20I World Cup https://f-bod.com/mitchel-johnson-has-delivered-his-verdict-on-indias-bowling-roster-for-the-t20i-world-cup/ Sun, 18 Sep 2022 16:02:17 +0000 https://f-bod.com/mitchel-johnson-has-delivered-his-verdict-on-indias-bowling-roster-for-the-t20i-world-cup/ Ever since the Board of Control for Cricket in India (BCCI) announced the Indian squad for the T20 World Cup 2022, cricket experts have been giving their opinion on the squad. In this episode, former Australian fast bowler Mitchell Johnson also made a big statement. Johnson says the bowling combination given by India is risky. […]]]>

Ever since the Board of Control for Cricket in India (BCCI) announced the Indian squad for the T20 World Cup 2022, cricket experts have been giving their opinion on the squad. In this episode, former Australian fast bowler Mitchell Johnson also made a big statement. Johnson says the bowling combination given by India is risky. The former fast bowler says India selected slower bowlers for Australia’s bouncy pitches.

Indian selectors trusted the quartet led by Jasprit Bumrah with Bhuvneshwar Kumar, Harshal Patel and Arshdeep Singh. At the same time, Mohammed Shami was kept on standby.

sportslite image credits

Johnson, who arrived in India to play Legends League, told PTI-language on the sidelines of LLC: “If you put one all-rounder (fast bowler), two spinners and four fast bowlers in the team, then it’s a bit risky. But India are planning to play two fast bowlers and one all-rounder (Hardik Pandya) and two spinners in the playing XI.

The former left arm fast bowler said: “In Australia you have to keep three fast bowlers in the squad. In Perth conditions, four fast bowlers will need to be hired. I think they planned and chose the team, but it can be risky with only four fast bowlers.

https://quiz.cricnews24.com/

With that, he said, “Stuff like that is funny (that everyone should be playing 145+). If someone can play over 145, you don’t need someone else plays at the same pace. You need people who support each other, work together.

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The basics of DNA and genetic systems https://f-bod.com/the-basics-of-dna-and-genetic-systems/ Sat, 17 Sep 2022 00:04:57 +0000 https://f-bod.com/the-basics-of-dna-and-genetic-systems/ A new link between cancer and aging? A new study in 2022 reveals a stimulating relationship between how long animals live and how quickly their genetic code mutates. Cancer is a product of time and mutations, so researchers studied its onset and impact in 16 unique mammals. A new perspective on DNA mutation expands our […]]]>

A new link between cancer and aging?

A new study in 2022 reveals a stimulating relationship between how long animals live and how quickly their genetic code mutates.

Cancer is a product of time and mutations, so researchers studied its onset and impact in 16 unique mammals. A new perspective on DNA mutation expands our understanding of aging and cancer development and how we may be able to control it.

Mutations, aging and cancer: an introduction

Cancer is the uncontrolled growth of cells. It is not a pathogen that infects the body, but a normal bodily process gone wrong.

Cells are dividing and multiplying in our body all the time. Sometimes during DNA replication, tiny errors (called mutations) appear randomly in the genetic code. Our body has mechanisms to correct these errors, and for much of our youth, we stay strong and healthy thanks to these corrective measures.

However, these protections weaken with age. The development of cancer becomes more likely as mutations escape our defenses and continue to multiply. The longer we live, the more mutations we carry and the likelihood of them manifesting as cancer increases.

A biological enigma

Since mutations can occur randomly, biologists expect larger life forms (those with more cells) to have a higher chance of developing cancer than smaller life forms.

Curiously, no association exists.

It’s one of the biggest mysteries in biology as to why massive creatures like whales or elephants rarely seem to get cancer. It’s called Peto’s paradox. Even weirder: some smaller creatures, like the naked mole rat, are completely resistant to cancer.

This phenomenon motivates researchers to look into the genetics of naked mole rats and whales. And while we’ve found that special genetic bonuses (like extra tumor-suppressing genes) benefit these creatures, a pattern of cancer rates in all other species is still poorly understood.

Cancer may be closely associated with lifespan

Wellcome Sanger Institute researchers report the first study to compare mutation rates with lifespan in animals.

Mutation rates are simply the rate at which species breed mutations. Mammals with shorter lifespans have very fast average mutation rates. A mouse undergoes nearly 800 mutations in each of its four short years on Earth. Mammals with longer lifespans have much slower average mutation rates. In humans (average lifespan of about 84 years), there are less than 50 mutations per year.

The study also compares the number of mutations at the time of death with other traits, such as body mass and lifespan. For example, a giraffe has about 40,000 times more cells than a mouse. Or a human lives 90 times longer than a mouse. What surprised the researchers was that the number of mutations at the time of death only differed by a factor of three.

Such weak differentiation suggests that there may be a total number of mutations that a species can collect before it dies. Since mammals reached this number at different speeds, finding ways to control the rate of mutations can help curb the development of cancer, delay aging and prolong life.

The future of cancer research

The results of this study raise new questions for understanding cancer.

Confirming that mutation rate and lifespan are strongly correlated requires comparison with non-mammalian life forms, such as fish, birds, and even plants.

It will also be necessary to understand what factors control mutation rates. The answer to this probably lies in the complexities of DNA. Geneticists and oncologists continue to study genetic curiosities such as tumor suppressor genes and their impact on mutation rates.

Aging is likely to be a confluence of many issues, such as epigenetic changes or telomere shortening, but if mutations are involved there may be hopes of slowing genetic damage or even reversing it.

Although only a first step, linking mutation rates to lifespan is reframing our understanding of cancer development, and it may open the door to new strategies and therapies to treat cancer or tame the number of health problems associated with aging.

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Talented Indie Artist Zhake Is Back With Another Banger, “Changing Seasons” https://f-bod.com/talented-indie-artist-zhake-is-back-with-another-banger-changing-seasons/ Mon, 12 Sep 2022 15:50:10 +0000 https://f-bod.com/talented-indie-artist-zhake-is-back-with-another-banger-changing-seasons/ IIf you particularly like the indie music genre and find the songs to be both soothing and refreshing at the same time, then you will fall in love with the indie artist. Zhake and his musical talents. He manages to write, compose, mix and produce the songs on his own, which proves his immense caliber. […]]]>

IIf you particularly like the indie music genre and find the songs to be both soothing and refreshing at the same time, then you will fall in love with the indie artist. Zhake and his musical talents. He manages to write, compose, mix and produce the songs on his own, which proves his immense caliber. The new track titled ‘Changing the Seasons’ creates a buzz among listeners due to its beautiful composition and well-constructed lyrics. The song is now out of Spotify, which is a collaboration between him and DALILA, and sets an enchanting vibe for the audience, allowing them to listen on repeat.

The artist, Zhake who is also known as Jake Mitchell has been working professionally on his music since 2018, and the new song, ‘Changing the Seasons’ shows how his growth as an artist has been. The track is beautifully composed and carries the essence of a soft and soothing vibe. The voices ideally complete the composition and correspond to the theme. However, the most enchanting element is the lyrics which are well constructed, expressive and yet so simple. You can listen to the track on Spotify along with other songs like ‘Night Lights’, ‘Broken Hearts’, ‘Best Jokes’, ‘Sorry Stories’, etc. and follow the artist on Facebook, Twitterand Instagram for more updates.

Song link: https://open.spotify.com/album/68EnjcFWMrP1fZ6ET2xXnA

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Genshin Impact: Dori Team Composition Guide https://f-bod.com/genshin-impact-dori-team-composition-guide/ Sat, 10 Sep 2022 08:31:00 +0000 https://f-bod.com/genshin-impact-dori-team-composition-guide/ Composition of the Dori team in Genshin Impact is one of the aspects that players should consider when building Dori. She requires different builds for each role, so players should adjust Dori’s gear accordingly. For example, if the team does not have a Dendro stamp, then the merchant should be the one holding the Deepwood […]]]>

Composition of the Dori team in Genshin Impact is one of the aspects that players should consider when building Dori. She requires different builds for each role, so players should adjust Dori’s gear accordingly. For example, if the team does not have a Dendro stamp, then the merchant should be the one holding the Deepwood Memories artifacts.


Related: Genshin Impact: How To Unlock Sumeru Forgeable Weapons

The composition of Dori’s team in Genshin Impact is deeply connected to Electro Elemental reactions, be it Hyperbloom, Quicken or even the classic Electro-Charged. Shortly, however, due to her resemblance to Kuki Shinobu, Team Dori’s composition in Genshin Impact may be quite similar to that of the former Shrine Maiden.

GAMER VIDEO OF THE DAY

Dori + Collei + Sucrose + Sangonomiya Kokomi

Hyperflowering in Genshin Impact occurs when the Dendro Cores created via Bloom’s reaction come into contact with Electro. Usually this can be quite complicated to create as players have to aim their electro shots to trigger Hyperbloom, but with Dori it has never been easier.

When Dori uses her Elemental Burst, she throws her Jinni on the ground. This Jinni will create a line that connects to the active character, and this line will inflict Electro DMG when it hits enemies. If players are moving, this line can also be used to deal Hyperbloom.

Related: Genshin Impact: How To Beat Jadeplume Terrorshroom (& Where To Find It)

With this Dori team comp, start with Kokomi casting her elemental skill, then use Sucrose’s burst and elemental skill. Next, fill the field with Dendro Cores using Collei, and finally pop Dori out to unleash an army of Hyperblooms. With 1000 EM, each Hyperbloom will deal around 30,000 damage.

Team roles

  • Dori: Healer, Hyperbloom Trigger
  • collei: Dendro activator, debuffer (4pc Deepwood Memories)
  • Sucrose: EM buffer, crowd control
  • Sangonomiya Kokomi: Hydraulic activator

Dori + Tighnari + Venti + Yae Miko

In this composition of Team Dori, Tighnari is the main damage dealer. Dori only exists here to protect the team. Also, since Venti is better equipped with Viridescent Venerer and Yae Miko should focus on damage, Dori should be the one holding 4pc Deepwood Memories to amplify Tighnari’s attacks.

If players have multiple constellations of Dori in Genshin Impactthe merchant can also be designed to deal damage using Elemental Mastery/Bonus Electro DMG/Critical Rate or DMG main artifact stats.

Team roles

  • Dori: Healer, Debuffer (4pc Deepwood Memories)
  • Tighnari: Sub-DPS
  • Sale: Battery, debuffer (4pc Viridescent Venerer)
  • Yae Miko: Sub-DPS

Dori + Tighnari + Kaedehara Kazuha + Raiden Shogun

Similar to the previous team, this Dori team comp also focuses on Quicken, Spread, and Aggravate. However, here Kaedehara Kazuha and Raiden Shogun are present to further improve the team’s DPS in Genshin Impact. Raiden Shogun will buff the entire team’s Elemental Burst DMG, while Kazuha will help Raiden Shogun deal massive numbers.

Team roles

  • Dori: Healer, Debuffer (4pc Deepwood Memories)
  • Tighnari: Sub-DPS
  • Kaedehara Kazuha: Buffer, Debuffer (4pc Viridescent Venerer)
  • Raiden Shogun: Sub-DPS, battery

Dori + Collei + Kamisato Ayato + Fischl

Kamisato Ayato in Genshin Impact Not only is he a decent primary DPS, but he’s also a great Hydro enabler. With Ayato’s Elemental Burst and Collei’s Dendro app, they can cooperate to produce Dendro cores. Then Dori should be the one to trigger the Hyperbloom.

Related: Genshin Impact: How To Beat Electro Regisvine (& Where To Find Him)

Meanwhile, Fischl is mostly there to help Kamisato Ayato deal damage. At a higher Constellation level, Fischl can deal a lot of extra damage if his team deals electro related reactions. Since this Team Dori comp is all about elemental reactions, Fischl’s Oz will deal endless damage.

Team roles

  • Dori: Healer, Hyperbloom Trigger
  • collei: Dendro activator, debuffer (4pc Deepwood Memories)
  • Kamisato Ayato: Main DPS, Hydro enabler
  • Fish: Sub-DPS

Dori + Kamisato Ayato Or Sangonomiya Kokomi + Xingqiu Or Yelan + Fischl

It’s hard not to think about Dendro with Dori now that the Dendro Elemental reaction is out in Genshin Impact. However, aside from Dendro, players can also opt for the classic Electro-Charged team. For this one any Hydro DPS can work, like Kamisato Ayato, Sangonomiya Kokomi or Tartaglia.

Next, players will need Electro units. Usually a fireworks composition consists of Fischl and Beidou. But since Dori is present, players can either use two of the three (or even all three at once).

If players opt for two Electro characters, the last unit can be a second Hydro. Units like Yelan and Xingqiu are both excellent under-DPS. With the recent Hydro Resonance buff, Yelan will perform even better in a dual Hydro team composition.

Team roles

  • Dori: Healer, electro-charged trigger
  • Kamisato Ayato or Sangonomiya Kokomi: Main DPS
  • Yelan or Xingqiu: Sub-DPS, Hydro Resonance
  • Fish: Sub-DPS

Genshin Impact is now available on Mobile, PC, PS4 and PS5. A Switch version is in development.

More: Genshin Impact: All Character Guides | Ascension mats, builds, weapons, teams, and tips for each character

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How to monitor body composition on your Samsung Galaxy Watch 4 https://f-bod.com/how-to-monitor-body-composition-on-your-samsung-galaxy-watch-4/ Sat, 03 Sep 2022 17:00:00 +0000 https://f-bod.com/how-to-monitor-body-composition-on-your-samsung-galaxy-watch-4/ The Samsung Galaxy Watch 4 is a premium smartwatch with nifty features that make it easy to keep up with your fitness routines. While it tracks common metrics like heart rate, steps, sleep patterns, and other metrics, it’s the first Samsung wearable device that can also measure body composition. Let’s see how the feature works […]]]>

The Samsung Galaxy Watch 4 is a premium smartwatch with nifty features that make it easy to keep up with your fitness routines. While it tracks common metrics like heart rate, steps, sleep patterns, and other metrics, it’s the first Samsung wearable device that can also measure body composition.

Let’s see how the feature works and how you can use it to track your weight loss and fitness goals.


Why should you measure body composition?

Body fat is one of the main factors in the development of diseases such as diabetes, heart disease and high blood pressure. According to this article from the American Journal of Clinical Nutrition, the ideal body composition for men and women varies with age. This makes ongoing body composition analysis a valuable tool for planning healthier lifestyles.

So what exactly is body composition?

Your body composition is the ratio of fat mass to muscle (or skeletal) mass. The Galaxy Watch 4 offers real-time body composition measurements using advanced Bioelectrical Impedance Analysis (BIA), a medical technique for measuring the electrical conductivity of living tissue.


Once set up, the smartwatch sends low-frequency electrical currents to your body through your wrist and measures resistance through fatty and hydrated muscle tissue. Signals encounter resistance as they pass through fatty tissue. It then determines the fat and water levels in your body by comparing the data points to over 2,400 values ​​from an extensive health database.

To get the most accurate reading on your Galaxy Watch, you’ll need to manually enter your age, height, weight, and gender. You can also keep a note of these guidelines from Samsung to get the most out of this feature.

Body composition measures, such as visceral fat, body mass index, and skeletal muscle mass, correlate with physiological function. This can help to better understand the potential risks associated with your lifestyle, genetic predisposition or other conditions. For athletes, it is especially useful to analyze and plan how much nutrition and exercise they should consume.

According to the National Strength and Conditioning Association, body composition is one of the most important measures for the overall fitness of athletes. For example, people with large muscle mass are likely to be better at basketball and swimming than at soccer and cycling. However, you should not use the tool if you are pregnant or have medical devices implanted in your body, such as a pacemaker.

Get started with body composition measurements on the Galaxy Watch 4

The Samsung Galaxy Watch 4 makes it easy to track your fitness goals. You can set personal goals and get tips and suggestions on what you can do to improve your health, as well as see how you’re progressing towards your goals.

To get started, download and install the Samsung Health app on your smartwatch. Next, you’ll need to set up your health profile to receive personalized health suggestions, track your daily exercise habits, and set nutrition and fitness goals.


To download: Samsung Health for Android | iOS (Free)

How to Use Body Composition Analysis (BCA) on Samsung Galaxy Watch 4

As we noted earlier, the body composition scan tool is a useful tool for gaining important insights into your health. Take a closer look at how to set up and use the feature.

Set up your goals and reminders

The tool can help you understand how weight and fat levels affect your metabolism, energy levels, and more. Follow these steps to set your goals and stay on track:

  1. On your smartphone, launch the Samsung Health app.
  2. Go to the section on body composition.
  3. Tap it and select The objectives set. You will now be asked to enter your weight, body fat percentage, and skeletal muscle targets.
  4. Note that you will also need to enter your height and gender in the Profile section (if you haven’t already) when setting up your body composition goals.
  5. If your entries conflict with the recommended targets, you can adjust them accordingly, based on the suggested ranges.

To configure notifications, scroll down and toggle the slider button to Receive reminder notifications. Choose how often you want to receive a notification reminding you to measure your body composition (once a day, every other day of the week or more frequently) as well as the time of day you want to be notified.

Measure body composition on your smartwatch

Although BMI tests have traditionally been used to measure your weight to indicate the presence of body fat, they are not as accurate as the BIA technology used in smart scales and high-end wearables such as the Galaxy Watch. 4. To get accurate body composition readings on your smartwatch, here’s what you’ll need to do:

  1. First, make sure you’re wearing your watch.
  2. Next, on your watch face, swipe left to access your Wear OS tiles until you come across the body composition section.
  3. Faucet Measureand select your gender.
  4. Enter your height and weight and press To confirm. You might consider using a regular or smart scale to accurately measure your weight.
  5. Follow the on-screen instructions to adjust your watch and place it higher on your wrist. Make sure it is securely attached.
  6. Now touch the House and Return touches with your fingers with the palm up. Your hands should not be in contact.

  7. Raise both arms to chest level and away from your body. Stay still while the watch takes your readings.
  8. After about 15-20 seconds, you will be able to see the results of your body composition readings as a quick summary.
  9. To get a better idea of ​​your measurements, you can also visit the Body Composition section of the Samsung Health app.


The measure can be useful for everyone, especially those at risk for diabetes or heart disease, as they have less muscle mass and are therefore more likely to develop these conditions. Knowing your body composition can help you determine if your physical performance is impaired or if you have gained too much weight.

Take a closer look at body composition assessments

Measuring body composition is easy with the Galaxy Watch 4. This feature provides detailed information to help you find the right balance of diet and exercise to achieve your goals and health goals. Plus, it’s simple to use and seems pretty accurate so far.

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